Primary Essentials

Better sleep. PMS support. Improved digestion. Glowing skin. Everything you need in drinkable multivitamin formulated exclusively for women in their cycling years.

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The most important part of supplementation is consistency!

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Elderflower Lemonade
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Cranberry Lemonade
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    Supports deep, restorative sleep

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    Balances mood throughout your cycle

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    Eases PMS & menstrual discomfort

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    Supports energy metabolism and skin radiance

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    Nourishes digestive health & microbiome

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    +20 essential vitamins & minerals

Product Description

Primary Essentials is a daily effervescent multivitamin drink for women ages 18-45. One sachet supports premenstrual comfort, healthy mood balance throughout your cycle, cellular energy metabolism, skin vitality, hydration, and digestive wellness—replacing the need for a separate multivitamin, probiotic, cycle support, and electrolyte blend in one simple daily drink.

Clinically studied botanicals are included at their researched doses. Chasteberry (Vitex agnus-castus, 40 mg) supports symptoms associated with PMS, including breast tenderness, hormonal comfort, and mood stability throughout the cycle. It is the most clinically validated botanical for PMS support: in a placebo-controlled trial, Vitex was associated with a significant reduction in Moos' Menstrual Distress Questionnaire scores, and in a separate randomized trial of 170 women, over half of the Vitex group achieved at least a 50% symptom reduction versus only 24% on placebo. Affron® saffron extract (28 mg) promotes a positive mood, stress resilience, and emotional balance at its clinically studied dose. Pomella® pomegranate extract (250 mg) provides rich antioxidant support for radiant skin and a healthy gut microbiome. Clinical research shows Pomella® supports short-chain fatty acid production, including beneficial propionate, in the gut, a beneficial fatty acid for the microbiome. Clinical research shows Pomella® supports short-chain fatty acid production in the gut, including propionate, a beneficial postbiotic. Activated BroccoRaphanin® (50 mg), concentrated broccoli seed extract standardized to 10% sulforaphane glucosinolate to support the body’s natural liver function and antioxidant defenses.

The nutrient base is built for cycling women specifically: 8 mg of chelated iron as ferric trisglycinate to help close the iron gap monthly bleeding creates, folate as methylfolate and B12 as methylcobalamin rather than their commercial counterparts, plus calcium citrate, magnesium citrate, VitaCholine® choline, and vitamins A, C, D3, E and menatto® K2 as MK-7. Better, not more - in the forms and amounts your body can actually use. Bacillus coagulans Unique IS-2® supports digestive health, stool regularity, and a healthy microbiome. Electrolytes provide 200 mg sodium and 100 mg potassium to support hydration and nervous-muscle system function.

Pour one sachet into 8-12 oz of water, stir, and enjoy once daily, with or without food. Non-GMO, gluten-free, vegetarian, no sugar added, no artificial flavors or colors.

Third-party tested and manufactured in the US in cGMP-certified facilities.

Two variables separate a formula that works from one that just reads well on a label: the form of each nutrient, and the amount.

Form decides whether your body can use it. Folate is included as L-5-methyltetrahydrofolate rather than folic acid, so it arrives already active and skips the metabolic conversion step that some women process less efficiently. B12 is methylcobalamin, not cyanocobalamin. Iron is ferric trisglycinate, a chelated form chosen because chelated iron absorbs better and is gentler on the stomach than standard iron salts in conventional multivitamins. Vitamin K2 is MK-7, which remains in circulation longer than other forms. Calcium and magnesium are bioavailable citrates.

Amount decides whether it delivers results. Many multivitamins list a clinically studied botanical at a fraction of the dose used in the research, a practice known as 'fairy dusting'. We include Chasteberry at 40 mg, Affron® at 28 mg and Pomella® at 250 mg, matching the exact amounts used in published research. Choline is also included at a meaningful dose, an amount standard multivitamins physically cannot accommodate.

If you bleed monthly you run an iron gap beyond what you consume in your diet, and the dietary guidelines treat iron as a nutrient of public health concern for menstruating women. This formula includes 8 mg of iron in a chelated form - a meaningful contribution alongside your diet, in a bioavailable form your stomach will tolerate.

The drink format is what makes that possible. A single sachet carries several grams of actives, so nothing has to be cut to fit inside a pill. It also means you are far more likely to take it—and consistency is the variable that matters most in feeling the benefits.

This formula isn't built for a generic audience. It is tailored specifically to what the female body depletes and requires during the cycling years.

Key ingredients include:

  • Chasteberry (Vitex agnus-castus) (40mg): The most clinically validated botanical for monthly cycle support (symptoms associated with PMS), promoting premenstrual comfort and helping balance mood throughout your cycle
  • Affron® Saffron Extract (28mg): Clinically studied to promote a positive mood, stress resilience, and emotional balance
  • Pomella® Pomegranate Extract (250mg): Clinically studied to support skin health from within and a healthy gut microbiome
  • Activated BroccoRaphanin® (50mg): Concentrated broccoli seed extract standardized to 10% sulforaphane glucosinolate to support natural liver function and cellular antioxidant defenses
  • Chelated iron (8mg as ferric trisglycinate): A well-absorbed, gentle form to help replenish iron lost during menstrual cycles
  • Essential vitamin and mineral complex: Bioavailable, high-quality nutrients designed to replace a standalone multivitamin
  • Probiotics (Bacillus coagulans Unique IS-2®): Clinically studied strain that supports the digestive system and a healthy microbiome
  • Balanced electrolytes: Supports optimal hydration when mixed with water and maintains healthy neuromuscular function

Serving Size: 1 Sachet (Cranberry Lemonade: 5.93gm / Elderflower Lemonade: 5.69gm)

Servings Per Container: 30

  • Calories 10
  • Carbohydrate 2 g — <1%**
  • Vitamin A (as 50% Retinyl Palmitate, 50% Beta Carotene) 350 mcg — 39%
  • Vitamin C (as Ascorbic Acid) 60 mg — 67%
  • Vitamin D3 (as Cholecalciferol) 25 mcg (1,000 IU) — 125%
  • Vitamin E (as d-Alpha-Tocopheryl Succinate) 7.5 mg — 50%
  • Niacin (as Niacinamide) (B3) 14 mg — 88%
  • Vitamin B6 (as Pyridoxine HCl) 5 mg — 294%
  • Folate (as L-5-Methyltetrahydrofolate Calcium Salt) 200 mcg DFE — 50%
  • Vitamin B12 (as Methylcobalamin) 10 mcg — 417%
  • Pantothenic Acid (as d-Calcium Pantothenate) (B5) 10 mg — 200%
  • Choline (as Choline Bitartrate) (VitaCholine®)† 110 mg — 20%
  • Calcium (as Calcium Citrate) 100 mg — 8%
  • Iron (as Ferric Trisglycinate) 8 mg — 44%
  • Magnesium (as Magnesium Citrate) 84 mg — 20%
  • Chromium (as Chromium Picolinate) 25 mcg — 71%
  • Sodium (as Sodium Bicarbonate) 200 mg — 9%
  • Potassium (as Potassium Bicarbonate) 100 mg — 2%
  • Saffron Extract (Crocus sativus L.) (stigma) (Affron®)† 28 mg — *
  • Pomegranate Extract (Punica granatum) (fruit) (Pomella®)† 250 mg — *
  • Chasteberry Extract (Vitex agnus-castus) (fruit) 40 mg — *
  • Broccoli Extract (10% sulforaphane glucosinolate) (seed) (Activated BroccoRaphanin®)† 50 mg — *
  • Vitamin K2 (as MK-7 [Menaquinone-7]) (menatto®)† 45 mcg — *
  • Bacillus coagulans (2 Billion CFU) (Unique IS-2®)† 15 mg — *

Other Ingredients (Cranberry Lemonade): Citric Acid, Natural Cranberry Flavor, Natural Lemon and Lime Flavors, Carrot Concentrate (Color), Silicon Dioxide

Other Ingredients (Elderflower Lemonade): Citric Acid, Natural Elderflower Flavor, Natural Lemon and Lime Flavors, Spirulina Concentrate (Color), Silicon Dioxide

**Percent Daily Values are based on a 2,000 calorie diet. *Daily Value not established.

Supplement Facts

Here's how Primary Essentials typically works over time:

Weeks 2-3: You may start to notice more energy support from the B-complex vitamins and electrolytes

Week 4: Mood stability from Affron® saffron 

Month 2: Gut health benefits and microbiome improvement from Bacillus coagulans Unique-IS2®; increased skin radiance from Pomella® pomegranate extract

Month 2-3: PMS support from chasteberry including relief from physical discomfort, breast tenderness and hormonal mood swings

Month 3+:  The full effects of essential nutrients like vitamin D3, iron and choline, as well as clinically-studied ingredients will be felt and sustained with consistent on-going use

Pour the contents of one sachet into a glass. Add 8-12 oz of water, stir, and drink.

Take one sachet daily, with or without food. Consistency matters more than timing: pick the moment you will actually repeat every day.

Take it every day of your cycle, not just the week before your period. The chasteberry research measured its results across consecutive monthly cycles of daily use. If iron on an empty stomach bothers you, take it alongside a meal.

One tin is a 30-day supply. If you miss a day, simply resume the next day.

When to Use

Daily, every day of your cycle.

This is the one worth being clear about: take it all month, not just the week before your period. The clinical research on chasteberry studied cumulative benefits over consecutive cycles of daily use, and the nutrient base - iron, folate, D3, choline - only works cumulatively.

Any time of day. There is no caffeine and no added stimulant in the formula, so morning, afternoon and evening may work. Pick the moment you will actually repeat.

With or without food. Alongside a meal is gentler if iron on an empty stomach bothers you.

Through your cycling years. If you enter your 40s and start noticing natural shifts in cycle length, sleep or mood, Midlife Essentials is designed specifically for the perimenopausal transition. If you become pregnant or start trying to conceive, Prenatal Essentials is formulated for those stages.

Our Medical Advisory Board formulated Primary Essentials to match published research at dosages proven to deliver results for women. This is uncommon in the supplement world–brands typically sprinkle many ingredients in too-small quantities.

Manufactured in US-based facilities at FDA registered sites, with cGMP certifications.We use third-party testing for independent verification of our quality. Ingredients included are Generally Recognized as Safe (GRAS). Our products are: 

  • Non-GMO
  • Gluten-free
  • Vegetarian*
  • No artificial flavors or colors
  • No sugar added

*contains shellac, a natural resin sourced from the Lac beetle

Designed to replace multiple supplements with one comprehensive solution for your hormonal stage.

Science & Research

Formulated with Purpose. Backed by Science.

Every ingredient in Primary Essentials was selected by our Medical Advisory Board to address the real health concerns women experience during cycling years while also ensuring overall nutritional needs are met.

58%

Reduction in Mood Disturbance Scores in four weeks [1]

25%

Improvement in sleep quality ratings in 28 days [2]

43%

Reduction in menstrual distress scores [3]

98%

Achieved normal stool consistency after 4 weeks [4]

Enhanced Absorption

Lifestage Specific

Science Backed Ingredients

Comprehensive Formula

Published In:
[1] Complementary Therapies in Medicine (Volume 33, August 2017). [2] Sleep Medicine (Volume 86, October 2021). [3] Archives of Gynecology and Obstetrics (Volume 264, 2000). [4] Probiotics and Antimicrobial Proteins (June 2020).

What’s inside

Our clinically backed ingredients

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MAXIMAL ABSORPTION. GENUINE DAILY ENJOYMENT.

What’s inside

Our clinically backed ingredients

Botanicals & Other Clinically-Backed Ingredients

PMS and cycle-related symptoms affect up to 85% of cycling-age women. We've included 40mg of chasteberry extract, shown in the research to significantly reduce breast tenderness, bloat, and mood changes associated with PMS. Combined with 28mg affron® saffron extract for mood support throughout the cycle, and 250mg Pomella® pomegranate extract for skin health, this comprehensive botanical blend replaces multiple cycle-support supplements with clinically-studied ingredients at research-backed dosages.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Saffron Extract
Clear plastic cup with red liquid on a red background Pomegranate Extract
Clear plastic cup with red liquid on a red background Chasteberry Extract

Probiotics

Our clinically studied probiotic strain of Bacillus coagulans Unique-IS2® supports digestive health and stool regularity, and promotes a healthy microbiome that may help with nutrient availability for the gut cells and overall nutrient absorption. Gut health affects hormone metabolism and the gut-brain connection—the communication pathway between your digestive system and brain that influences mood, stress response, and energy levels throughout your cycle. Since your gut produces about 90% of your body's serotonin (a key mood neurotransmitter), supporting gut health directly impacts how you feel during your cycle including how severely you experience PMS.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Bacillus Coagulans

Vitamins & Minerals

Cycling women have specific nutritional needs, including higher iron requirements due to the significant iron loss during regular menstruation. Our formula provides methylated B-vitamin complex, bioavailable iron, and other essential vitamins and minerals in forms your body can readily use. These nutrients are in their bioactive form that your body needs during this phase of life in dosages that matter, letting you eliminate the need for a separate multivitamin, iron supplement, and B-complex formula while providing targeted support for your menstrual cycle.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Iron
Clear plastic cup with red liquid on a red background B-Vitamin Complex
Clear plastic cup with red liquid on a red background Vitamin K2
Clear plastic cup with red liquid on a red background Vitamin D3

Electrolytes

Our electrolyte blend (200mg sodium, 100mg potassium) supports optimal hydration and nervous system function when made into a beverage. Unlike hydration products with up to 1000mg of sodium, our formulation delivers an amount more suitable without excess sodium that may cause bloating.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Sodium
Clear plastic cup with red liquid on a red background Potassium

How we compare

Biologica Essentials deliver comprehensive nutrition and targeted relief, all designed for the woman who you are today.

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Greens

Multivitamins

Probiotics

Designed For Female Lifestages

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Alleviates Key Health Concerns

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Essential Vitamins and Minerals

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Clinically Studied Dosages

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Supports Gut Health

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Electrolytes

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WHAT’S BEHIND OUR LIFESTAGE FORMULATIONS

THE SCIENCE OF YOUR PRIME CYCLING YEARS

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Natural monthly hormonal fluctuations are normal for cycling women, but can also cause a whole host of symptoms, everything from mood to energy to skin health. Primary Essentials provides targeted nutrition for this dynamic life stage, with ingredients that support your body through natural cycle variations, rather than trying to combat them.

Learn more — hormones 101

TASTES LIKE A DAILY RITUAL SHOULD

We tested dozens of flavors because your daily supplement shouldn't taste like medicine. As a result of this research, and without any sugar, each Biologica Essential comes in a range of indulgent, flavor-forward options from fruit from real farms—think bright, juicy, and never too sweet. It's the kind of daily ritual you'll actually want to maintain.

Product Reviews

4.8
Rated 4.8 out of 5 stars
Based on 87 reviews
99%would recommend this product
87 reviews
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    ash
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    Rated 4 out of 5 stars
    1 week ago
    4 Stars

    Arrived very late! But nicely packaged, have yet to see results!

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  • J
    Jessica
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    A true fan

    I am approaching month 3 and i absolutely feel great. PMS/periods feel better and general mood is up. I Have been sleeping well and waking up with more energy. I will definitely be continuing! The cherry on top is how delicious it is! I look forward to taking it like I would a delicious beverage.

    Well done!

Got more questions?

Frequently Asked Questions

Primary Essentials is designed to support your nutritional needs during your menstrual years. The ingredients included provide foundational nutrition and cycle support that when used regularly over time can help women experience less symptoms associated with their cycle. If the reason for using birth control is for pregnancy prevention, we recommend reviewing supplements with your qualified healthcare provider so they can help you make the best decision for your personal situation.

Primary Essentials supports your body's natural hormonal rhythms with ingredients like chasteberry that is research-backed for cycle support. However, it's a nutritional supplement, not a medical treatment for cycle irregularities. For significant cycle concerns, consult your healthcare provider.

Take it every day! The consistent use of herbs and nutrients targeted for hormonal support are best used throughout the cycle so that the body has what it needs during the follicular phase and the luteal phase, and is provided a holistic routine. The ingredients work cumulatively to support your body's natural rhythms, not just during symptomatic times.

While our ingredients are generally recognized as safe, we recommend consulting your healthcare provider before using any supplements during pregnancy or breastfeeding. We are considering developing a prenatal and would like to hear from you if you're interested in this. After pregnancies, our Primary Essentials can be exceptionally restorative.

Unlike generic multivitamins, Primary Essentials is specifically formulated for women in their cycling years, with supportive botanicals like chasteberry and Affron® saffron extract, Pomella® pomegranate extract, targeted and bioavailable vitamins and minerals, and a clinically studied probiotic strain Unique-IS2®. Plus, our effervescent format provides enhanced absorption and a daily experience you'll actually enjoy.

Primary Essentials supports your body's hormonal rhythms regardless of cycle length or regularity. The nutrients and botanicals work cumulatively to provide foundational support. For significant irregularities, consult your healthcare provider while continuing daily nutritional support.

Our formula includes Pomella® pomegranate extract, which supports skin health from within through gut microbiome support. While this may help your skin overall, it is not specific to hormonal acne. Many women notice skin improvements over 4-8 weeks of consistent use.

Our formulas are designed to complement your existing health routine. However, we always recommend consulting with your healthcare provider before starting any new supplement, especially if you're taking medications or have specific health conditions. They know your medical history best.

Primary is designed to sync with your body’s natural rhythms. Many feel an initial lift in energy and hydration within the first few weeks from B-complex vitamins and electrolytes. Mood stability and sleep quality typically improve over 4-8 weeks of consistent use. As you move into months 2 and 3, you’ll notice systemic shifts—from improved skin radiance and digestion to the clinically-backed benefits for PMS relief. Because hormonal health is cumulative, we recommend a 90-day trial for full optimization.
Hand pouring a clear liquid into a glass with a dark background Hand pouring a clear liquid into a glass with a dark background

Citations

58% Reduction in Mood Disturbance Scores in four weeks

"affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial."

  • Authors: Kell, G., Rao, A., Beccaria, G., Clayton, P., et al.
  • Published In: Complementary Therapies in Medicine (Volume 33, August 2017).
  • The 58% Statistic: the 58% figure is a commonly cited calculation from this specific trial's data. It represents the percentage decrease in the Total Mood Disturbance (TMD) score for participants taking the 28 mg/day dose compared to their baseline after 4 weeks.

25% Improvement in sleep quality ratings in 28 days

"An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study."

  • Authors: Lopresti, A. L., Smith, S. J., & Drummond, P. D.
  • Published In: Sleep Medicine (Volume 86, October 2021).
  • The 25% Statistic: refers to a 25% increase in the Restorative Sleep Questionnaire (RSQ) score after 28 days of supplementation. The RSQ measures how "restored" or energized a person feels upon waking, rather than just the number of hours they slept.

43% Reduction in menstrual distress scores

"Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS)."

  • Authors: Berger, D., Schaffner, W., Schrader, E., et al.
  • Published In: Archives of Gynecology and Obstetrics (Volume 264, 2000).
  • The 43% Statistic: this figure (rounded from 42.5% in the raw data) represents the average reduction in the Moos' Menstrual Distress Questionnaire (MMDQ) scores after three months of treatment.

98% Achieved normal stool consistency after 4 weeks

"Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study."

  • Authors: Madempudi, R. S., Neelamraju, J., Ahire, J. J., Gupta, S. K., & Shukla, V. K.
  • Published In: Probiotics and Antimicrobial Proteins (June 2020).
  • The 98% Statistic: at the start of the study, 0% of the participants had normal stool consistency. By the end of 4 weeks, 98% of those in the probiotic group achieved "normal" stool form (defined as Type 3, 4, or 5 on the Bristol Stool Chart).

Primary Essentials

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Primary Essentials

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