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Role Of Pomegranate Extract in the body
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HEALTHY GUT MICROBIOME — promotes the growth of beneficial bacteria that convert pomegranate compounds into bioactive metabolites
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PROMOTES SKIN RADIANCE with clinical research demonstrating support for healthy skin appearance and texture, through the gut-skin connection, over just four weeks
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SUPPORTS ANTIOXIDANT ACTIVITY — provides a significant increase in blood antioxidant capacity supporting cellular activity and the body's natural defenses against oxidative stress
Why We Use It
Pomegranate Extract (Punica granatum) (fruit) - Pomella®
Notice your skin lacking its former glow? Dealing with unexpected digestive issues despite no changes in your diet? Your gut-skin connection is sending you signals. The appearance of your skin and your digestive health are linked through a fascinating gut-skin connection.
People have valued pomegranate for over 4,000 years, from Persian feasts to Egyptian tombs, because they instinctively recognized its connection to vitality from the inside out. Our Primary Essentials and Postmenopause Essentials feature Pomella®, a patented pomegranate extract with clinical backing that works through the gut-skin axis, that fascinating relationship between your digestive health and skin appearance.
These aspects of skin appearance are often linked to what's happening inside your body:
You may have heard of ellagic acid as a standalone solution for skin health. Even though ellagic acid converts to urolithin in the body, its effectiveness may be limited for skin health when you start with ellagic acid and not punicalagins. Research on whole pomegranate extract containing punicalagins, like Pomella®, consistently demonstrates more pronounced levels of urolithins in the body, versus their production when consuming pure ellagic acid alone.
Clinical studies confirm that 250-300mg of Pomella® creates meaningful shifts in your gut microbiome, increasing beneficial bacterial families and species, like Roseburia and Faecalibacterium prausnitzii, while supporting an increased production of short-chain fatty acids by 162% for propionate and 38% for acetate.
This gut-skin connection explains why many women notice improvements in both digestive comfort and skin appearance; they're interconnected systems that Pomella® supports simultaneously.
People have valued pomegranate for over 4,000 years, from Persian feasts to Egyptian tombs, because they instinctively recognized its connection to vitality from the inside out. Our Primary Essentials and Postmenopause Essentials feature Pomella®, a patented pomegranate extract with clinical backing that works through the gut-skin axis, that fascinating relationship between your digestive health and skin appearance.
These aspects of skin appearance are often linked to what's happening inside your body:
- Reduced radiance despite consistent skincare routines
- Skin texture changes that topical products haven’t addressed
You may have heard of ellagic acid as a standalone solution for skin health. Even though ellagic acid converts to urolithin in the body, its effectiveness may be limited for skin health when you start with ellagic acid and not punicalagins. Research on whole pomegranate extract containing punicalagins, like Pomella®, consistently demonstrates more pronounced levels of urolithins in the body, versus their production when consuming pure ellagic acid alone.
Clinical studies confirm that 250-300mg of Pomella® creates meaningful shifts in your gut microbiome, increasing beneficial bacterial families and species, like Roseburia and Faecalibacterium prausnitzii, while supporting an increased production of short-chain fatty acids by 162% for propionate and 38% for acetate.
This gut-skin connection explains why many women notice improvements in both digestive comfort and skin appearance; they're interconnected systems that Pomella® supports simultaneously.
In Your Formula
You’ll find Pomegranate Extract in:
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Postmenopause Essentials$79 $59 -
Primary Essentials$79 $59
References
Pomegranate: A review of the heavenly healer's past, present, and future
Mohammadi M, Boghrati Z, Emami SA, Akaberi M. Pomegranate: A review of the heavenly healer's past, present, and future. Iran J Basic Med Sci. 2023;26(11):1245-1264.
Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate Extract on the Gut Microbiome and Short-Chain Fatty Acids
Sivamani RK, Chakkalakal M, Pan A, et al. Prospective Randomized, Double-Blind, Placebo-Controlled Study of a Standardized Oral Pomegranate Extract on the Gut Microbiome and Short-Chain Fatty Acids. Foods. 2023;13(1):15.
Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis
Chakkalakal M, Nadora D, Gahoonia N, et al. Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis. J Clin Med. 2022;11(22):6724.
Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
Mertens-Talcott SU, Jilma-Stohlawetz P, Rios J, Hingorani L, Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. J Agric Food.
Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing pomegranate extract pharmacokinetics in humans
Wang YH, Mondal G, Khan W, Gurley BJ, Yates CR. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing pomegranate extract pharmacokinetics in humans. J Pharm Biomed Anal. 2023 Sep 5;233:115477.
Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin
Dimitrijevic J, Tomovic M, Bradic J, Petrovic A, Jakovljevic V, Andjic M, Živković J, Milošević SĐ, Simanic I, Dragicevic N. Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin. Pharmaceutics. 2024 Mar 26;16(4):458.
