Hormones 101

Supports Healthy Sleep Quality in 28 Days With Clinical-Dose Saffron

Getting quality sleep shouldn't require guesswork or fairy-dust dosing. In a 28-day randomized, double-blind, placebo-controlled trial published in the Journal of Clinical Sleep Medicine, 28mg of affron^® saffron extract taken daily during daytime hours significantly improved the quality of occasional sleep challenges compared to placebo in adults with self-reported poor sleep.

The trial used validated assessment tools including the Pittsburgh Sleep Diary and Restorative Sleep Questionnaire to measure changes in sleep quality over the 4-week period. Participants in the saffron group reported measurable improvements in both falling asleep and reducing occasional daytime grogginess, demonstrating that when formulated at clinically studied doses, botanical ingredients can provide meaningful support for restful sleep.

Brain Wave Studies Show Support for Alpha Brain Wave Activity Within 60 Minutes

Mental calm isn't just a feeling—it's measurable through brain activity. Research using electroencephalogram (EEG) technology demonstrates that 100mg of PharmaGABA^® supports a healthy alpha-to-beta brain wave ratio within 60 minutes of consumption. Alpha waves are associated with calm, focused mental states, while elevated beta waves are often observed during periods of everyday stress.

In a separate 12-week randomized controlled trial of 60 healthy adults, participants taking 100mg of GABA daily showed significantly improved scores in Motor Speed, Visuospatial/Constructional ability, and Delayed Memory assessments compared to placebo. The research demonstrates that clinically meaningful dosages of GABA can support both a healthy response to stress and longer-term cognitive function—measurable benefits that go beyond subjective reporting.

Supports Comfort During the Menstrual Cycle

Decades of clinical research have validated chasteberry's role in supporting women through monthly hormonal shifts. In a prospective, multicenter study involving 43 women with common monthly menstrual challenges, chasteberry extract was evaluated over three menstrual cycles using the validated Moos' Menstrual Distress Questionnaire (MMDQ).

Results showed a 42.5% reduction in MMDQ scores by the end of treatment, with the most significant improvements observed in menstrual discomfort, support for positive mood, and maintaining healthy fluid balance. Notably, 20 out of 43 participants were classified as "responders"—experiencing at least a 50% reduction in premenstrual discomfort. A separate randomized, double-blind, placebo-controlled study of 128 women found significant improvements across all six measured common monthly experiences including headache, nervousness, restlessness, sadness, breast swelling and discomfort, and bloating, when compared to placebo.

Chromium Picolinate Supports Healthy Body Composition

Maintaining lean body mass becomes increasingly important as we age, especially during periods of hormonal change, when hormonal shifts affect body composition. In a randomized, double-masked, placebo-controlled study of 154 participants over 72 days, chromium picolinate supplementation at 200mcg daily led to statistically significant improvements in the Body Composition Improvement index—a measure that accounts for both metabolism of body fat and maintenance of fat-free mass.

A separate bioavailability study comparing commercially available chromium supplements found that chromium picolinate demonstrated superior acute absorption compared to other forms. We chose Chromax^® chromium picolinate specifically because research indicates it's absorbed up to 15 times better than non picolinate forms, as measured by urinary chromium excretion.

Vitamin K2 MK-7 Activated Bone-Building Proteins in 12 Weeks

Strong bones require more than calcium and vitamin D—they need the right form of vitamin K2 to support healthy calcium utilization for the bone matrix.. In a double-blind, randomized controlled trial, 120 healthy adults took either 100mcg of MK-7 (the form of vitamin K2 in menatto^®) or placebo daily for 12 weeks.

The MK-7 group showed significantly improved osteocalcin γ-carboxylation—a key biological indicator of healthy bone metabolism, a necessary process for long-term bone maintainenance—compared to placebo. Osteocalcin is the protein responsible for binding calcium to the bone matrix, and it requires activation by vitamin K2 to function properly. A separate pharmacokinetic study demonstrated that MK-7 has superior bioavailability compared to the MK-4 form of vitamin K2, with serum levels remaining elevated for up to 48 hours after a single dose. This extended presence in the bloodstream means consistent support for your maintenance of healthy bones throughout the day.