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Water Bottle
Your daily hydration companion.

Water Bottle
Your daily hydration companion.
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Great way to save and achieve your health goals
This delicious tasting beverage packs 20+ vital ingredients, designed specifically for perimenopausal women.
Promotes calm & emotional balance
Supports deep, restorative sleep
Sharpens focus & cognitive clarity
Supports energy metabolism
Nourishes digestive health & microbiome
+20 essential vitamins & minerals
The most important part of supplementation is consistency!
A daily effervescent multivitamin for women in perimenopause that supports mood balance, sleep quality, energy metabolism, hydration, and digestive health.
Product Description
Midlife Essentials is a daily effervescent multivitamin drink for women ages 40-55 in perimenopause. One daily sachet supports mood balance, calm focus, restful sleep, a healthy response to everyday stress, energy metabolism, hydration, and digestive health - replacing your generic multivitamin, probiotic, sleep aids, mood supports, and electrolyte powder with a single drink.
Three clinically studied actives are included at their researched doses. Affron® saffron extract (28 mg) promotes mood balance and more restful sleep. In a 12-week randomized controlled trial of perimenopausal women aged 40-60, 28 mg of Affron® daily significantly supported emotional well-being and positive mood compared to placebo. Alphawave® L-theanine (200 mg) supports a calm mind and promotes relaxed concentration without drowsiness, and has been shown to significantly increase alpha brainwave activity, a marker of relaxation. PharmaGABA® (100 mg) is a functional amino acid that helps calm the mind and supports a healthy response to occasional stress, with EEG research showing significant increases in alpha waves within 30 minutes.
The nutrient base is built to fill real dietary gaps: vitamins A, C, D3, E and menatto® K2 as MK-7, a full B-complex in bioavailable forms including methylfolate and methylcobalamin, plus calcium citrate, magnesium glycinate, and choline. Better, not more - in the forms and amounts your body can actually use. menatto® K2 supports bone health along with vitamin D3, calcium and magnesium. Bacillus coagulans Unique-IS2 supports digestive health, stool regularity, and a healthy microbiome. Electrolytes provide 200 mg sodium and 100 mg potassium to support hydration and nervous-muscle system function once mixed with water.
Pour one sachet into 8-12 oz of water, stir, and enjoy once daily, with or without food. Non-GMO, gluten-free, vegetarian, no sugar added, no artificial flavors or colors.
Third-party tested and manufactured in the US in cGMP-certified facilities.
Designed to replace multiple supplements with one comprehensive solution for your hormonal stage.
OB/GYN formulated
Third-party tested
Clinical doses
30-day money back
Designed for the 5-10 tricky years before menopause
Most women never get a formal diagnosis, and you do not need one to feel it.
“The 3AM wake-up is the #1 complaint I hear from women in their 40s. We formulated for it.”
The 3AM wake-ups.
Promotes more restful sleep so you wake up alert
The moods that shift without warning.
Promotes mood balance and a calm, relaxed state
Reduce the mid-meeting mental static.
Relaxed concentration at the critical moments. No drowsiness and no caffeine.
Avoid the afternoon energy wall.
Supports steady energy metabolism all day
Better poops, less bloat
Supports digestive health, stool regularity and a healthy microbiome
How one sachet does it
Every ingredient at clinically-studied doses, third-party tested. No sugar, no fillers, no fairy-dust ingredients.
SUPPORT
Affron® Saffron 28mg · Alphawave® L-theanine 200mg · PharmaGABA® 100mg
Affron® saffron is clinically studied to significantly improve mood and sleep quality.
NOURISH
All essential vitamins incl. A, C, D, E, K + full B-complex · Calcium · Magnesium · Choline
Bioavailable forms, including methylated B-vitamins and choline, for the gaps common in perimenopause.
BALANCE
Bacillus coagulans Unique-IS2®
A clinically studied strain for digestive health and a balanced microbiome.
HYDRATE
Sodium 200mg · Potassium 100mg · Magnesium glycinate
Daily hydration designed for a woman's biology Hydration support with doses designed specifically to drive everyday performance for women.
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Read the label
Every ingredient, listed on the label at the dose the clinical research used. Nothing hides in a "wellness blend." And the form matters as much as the amount.
Third-party tested for independent purity and potency verification
Clinically-studied doses, disclosed per serving
Bioavailable forms — magnesium glycinate, methylfolate, K2 as MK-7
Made in cGMP-certified US facilities
The nutrient most multivitamins skip
Choline is a bulky nutrient. A capsule physically cannot hold it at a meaningful amount, so most multivitamins cut it to a trace or leave it out entirely. A drinkable sachet carries several grams of actives, so nothing has to be trimmed to fit.
110 mg
VitaCholine® per sachet
A real amount, not a trace.
20%
Of the Daily Value
Supports cellular health and energy metabolism.
0 mg
In most general multivitamins
Cut to fit a capsule. Not a clinical decision.
Clinical results
−58%
Mood disturbance scores
In 4 weeks — Affron® saffron, placebo-controlled trial[1]
+25%
Sleep quality ratings
In 28 days — Affron® saffron extract, randomized double-blind study[2]
+60%
Calm focus ratings
After a single dose — Alphawave® L-theanine, EEG-monitored study[3]
60min
Salivary cortisol levels
Significant drop within an hour of a single dose — Alphawave® L-theanine[3]
“Calm isn't just a vibe. Clinical studies show GABA promotes relaxing alpha brain waves in as little as 30 minutes.”
Dr. Maggie Luther · ND
30-Day Money Back Guarantee
These are trials of our key ingredients at the doses we use — not of the finished formula. Published in: [1] Complementary Therapies in Medicine (Volume 33, August 2017). [2] Sleep Medicine (Volume 86, October 2021). [3] BioFactors (Volume 26, 2006). *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulated by doctors
Board-certified clinicians who see every day how much targeted supplementation matters for women's health.
MD, OB/GYN · Chief Medical Advisor
In my practice, I see women at every hormonal stage struggling with symptoms that are dismissed or undertreated. Biologica’s formulations address the real biological shifts happening in women’s bodies with ingredients dosed to match the clinical research.
VP Regulatory & Innovation
We built each formula to be truly comprehensive — vitamins, minerals, electrolytes, probiotics, and targeted botanicals in one serving. Women can replace multiple products with one delicious drink.
Breast Surgeon · Medical Advisor
“Preventive health requires more than good intentions — it demands quality ingredients at therapeutic doses. As a surgeon, I value evidence-based approaches, and Biologica’s commitment to clinical research and third-party testing reflects the rigor women’s health deserves.”
“Perimenopause is the most under-supported transition in women's health.”
Evaluation point
Who it's made for
What's in it beyond vitamins & minerals
How much of each you actually get
The quality of what's inside
What your morning looks like
Midlife Essentials
Women 40–55, in perimenopause
All essential vitamins + clinically-backed support for focus, mood, sleep and gut. And a female-dosed electrolyte blend for hydration.
The same amounts used in the clinical trials showing significant results
Premium, trademarked ingredients like Affron® saffron, Alphawave® L-theanine, and PharmaGABA®
One delicious drink
Standard prenatal
One formula for every age
Many things you don't need
Sub-clinical Dosage
Mixed
Struggling to swallow green sludge or gummies with potency issues (not actually getting what they claim).
Buying it separately
$231/mo — see the mathYou work it out yourself
Five more bottles to buy
You research every dose
Different on every label
6–8 bottles on the counter
Midlife Essentials
Greens powder
Who it’s made for
Women 40–55, in perimenopause
One formula for every age
Beyond vitamins & minerals
Mood, sleep, focus and gut support, plus female-dosed electrolytes
A broad blend, little targeted support
How much you actually get
The amounts used in the clinical trials
Sub-clinical dosage
Quality
Affron®, Alphawave®, PharmaGABA®
Proprietary blends
Your morning
One delicious drink
Green sludge
Midlife Essentials
Buying it separately
Who it’s made for
Women 40–55, in perimenopause
You work it out yourself
Beyond vitamins & minerals
All essential vitamins + clinically-backed support for focus, mood, sleep and gut. And a female-dosed electrolyte blend for hydration.
Five more bottles to buy
How much you actually get
The same amounts used in the clinical trials showing significant results
You research every dose
Quality
Premium, trademarked ingredients like Affron® saffron, Alphawave® L-theanine, and PharmaGABA®
Different on every label
Your morning
One delicious drink
6–8 bottles on the counter
Replaces the separate supplements on your counter. Bought separately, at the same clinical doses: $231/mo As little as $1.32 a day for your first 30 days
The full breakdown ↓The third column, priced out
Everything in one sachet, priced out one bottle at a time, at the same clinical doses.
Multivitamin
Methylated B-complex, A, C, D3, E, K2 — bioavailable forms
$21
Calcium + magnesium glycinate
The magnesium form studied for sleep quality
$18
Choline
Rarely dosed meaningfully in a multivitamin
$18
Affron® saffron
28mg — the exact dose used in the mood and sleep trials
$45
Alphawave® L-theanine
200mg — the dose shown to raise alpha brainwaves
$25
PharmaGABA®
100mg — clinically studied for occasional stress
$34
Bacillus coagulans Unique-IS2®
A clinically studied probiotic strain
$35
Electrolytes
200mg sodium, 100mg potassium — 30 servings
$35
The first 90 days
Women in perimenopause have very distinct needs. We've used clinical research to design Midlife Essentials so it delivers needed relief and support at critical junctures in your life.
Week 1
More calm and less stressed immediately, since the effects of L-theanine and GABA both work shortly after consumption and over time
Weeks 2-3
More energy support from the B-complex vitamins and electrolytes
Weeks 4-6
Mood stability and sleep quality improvement from Affron® saffron and magnesium glycinate
Month 2
Gut health benefits and microbiome improvement from Bacillus coagulans Unique-IS2®; symptoms of perimenopause improve from Affron® saffron
Month 3+
The full effects of essential nutrients like vitamin D3, choline and vitamin E, as well as other clinically studied ingredients will be felt and sustained with consistent use
Where it works hardest
What the same sachet is supporting, every day you take it.
Mind
Daily
Calm focus
Mood
Daily
Mood balance
Sleep
Nightly
Restful sleep
Gut
Every meal
Digestive support
How it tastes
The supplement that works is the one you never skip. Every flavor is natural and sugar-free, with no chalky aftertaste.
No added sugar
Naturally flavored
Thoroughly mixes without gums
“I am approaching month 3 and I absolutely feel great… The cherry on top is how delicious it is.”
Individual results may vary. This customer's experience may not be typical. Shared with permission.
Passion Fruit & Blackcurrant
Bright and tart
Cranberry Lemonade
Crisp and citrusy
Product reviews
4.6
Based on 119 reviews
87% would recommend this product
Every review is published, including the critical ones. We answer them on this page rather than by email.
“So glad I found this, love the taste.”
“The texture is chalky when mixed with water and it does not mix the best, but the passion fruit flavor is tolerable. I like the health benefits.”
Biologica Wellness replied
The granules you're seeing are completely normal — real botanicals settle. It's best enjoyed with a straw, stirring before each sip.
“I like the product, though there are ingredients that are soluble that should be used. I sell ingredients for a living and work with a lot of formulators. Using soluble ingredients would be a game changer for this product.”
Biologica Wellness replied
We appreciate your feedback. We actually reformulated the product, and the updated version is designed to be more soluble and improve the overall mixing experience.
“Day 5 and nothing. Just feel more bloated and filled with air. I'd like to return and get my money back.”
Biologica Wellness replied
Day five is early — L-theanine and GABA work quickly, but mood and sleep changes from saffron typically take four to six weeks, and the probiotic can cause temporary gas as your microbiome adjusts. Try mixing into 12 oz rather than 8. You are still inside the 30-day window, so a full refund is available — we have emailed you to arrange it.
Already on something that works
Not buried in an accordion, because it is usually the question that decides everything else.
With HRT
Midlife Essentials contains no hormones and no phytoestrogens. It supports mood balance, sleep quality and stress management through separate pathways, and there is nothing in the formulation that interacts directly with hormone therapy. We still recommend discussing any new supplement with your qualified healthcare provider.
With an SSRI or anxiety medication
Our formula contains complementary nutrients that support mood and stress management through different pathways than prescription medications. As always, consult your healthcare provider before adding supplements to any psychiatric medication regimen.
With your other supplements
Generally fine, and usually unnecessary — this is built to replace most of them. Review your full regimen with your provider, and watch for doubling up on vitamin D, magnesium or a separate multivitamin.
Ingredients are Generally Recognized as Safe (GRAS). These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Straight answer
We do not make claims about hot flashes. Saffron does not act on estrogen, so this is not a vasomotor product. Where Midlife Essentials is designed to help is on psychosocial factors of perimenopause - mood, focus, sleep, and occasional stress.
Risk-free
They order it quarterly, drink it daily and stop thinking about it — which is the whole point.
30-day money back
One line to help@biologica.com and your first order is refunded in full. Keep the tin.
Skip, pause or cancel
Change the delivery date, skip a shipment, or stop entirely from your account.
HSA/FSA eligible
Pre-tax dollars save an average of 30%.
$39.50
$79
50% off your first 30 days
30 sachets, shipped free. Then $54/month, billed $162 every 3 months. Cancel anytime.
select flavor
Cranberry lemonade
Passion Fruit & Blackcurrant
30-day money back · cancel anytime
“All the supplements recommended to me, in one drink”
— laine · 46
FAQ
Pour one sachet into a glass, add 8-12 oz of water, stir, and drink. Take once daily, with or without food.
Mood balance, mental focus and relaxed concentration, more restful sleep, a healthy response to occasional stress, energy metabolism, hydration, and digestive health and a healthy microbiome. It also fills the everyday nutrient gaps a separate multivitamin would cover.
Clinically studied botanicals at their researched doses. Affron® saffron extract at 28 mg, Alphawave® L-theanine at 200 mg, and PharmaGABA® at 100 mg. Alongside those, a complete bioavailable vitamin and mineral complex (A, C, D3, E, menatto® K2 as MK-7, a full B-complex with methylfolate and methylcobalamin, calcium citrate, magnesium glycinate, choline), the Bacillus coagulans Unique-IS2 probiotic strain, and electrolytes at 200 mg sodium and 100 mg potassium.
No. Midlife Essentials contains no hormones and is not hormone replacement. It is a dietary supplement built from vitamins, minerals, amino acids, a probiotic, and botanical extracts. It is not a substitute for hormone therapy, and it will not interfere with a decision you make with your provider about one.
Because it is built to replace a separate multivitamin, probiotic, and electrolyte mix, check for nutrient overlap before you stack it with anything. If you take prescription medication, are pregnant or nursing, or are managing a medical condition, talk with your healthcare provider before starting any supplement.
Individual experiences vary. Research on Alphawave® L-theanine and PharmaGABA® measured alpha brainwave responses within the first couple hours of consumption. Clinical studies on 28 mg Affron® saffron measured mood and sleep support over 4 to 12 weeks of daily use. While closing dietary nutritional gaps with bioavailable vitamins and minerals takes time, and consistent use. We recommend taking it daily for at least 8 to 12 weeks to evaluate its full benefits.
Real botanicals settle — that's what you're seeing, not additives or fillers. We reformulated the powder to dissolve better, and it's best with a straw: stir before each sip and swirl the glass near the end.
Third-party tested for independent purity and potency verification of quality, and manufactured in the US in cGMP-certified facilities registered with the FDA. Non-GMO, gluten-free, vegetarian, no sugar added, no artificial flavors or colors.
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