Midlife Essentials

Midlife Essentials

Feel calm and energized today. Sharper focus and better sleep in weeks. Thrive through perimenopause in two months.

From /Day SachetsAge: 40-55
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The most important part of supplementation is consistency!

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    Includes critical nutrients

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    Promotes calm & emotional balance

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    Supports deep, restorative sleep

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    Sharpens focus & cognitive clarity

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    Supports energy metabolism

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    Nourishes digestive health & microbiome

Key ingredients include:

  • All essential vitamins, including A, C, D, E, K and a full B-complex
  • Calcium
  • Magnesium
  • Affron® saffron extract
  • L-Theanine (Alphawave®)
  • GABA (PharmaGABA®)
  • Probiotics (Unique-IS2®)
  • Choline
  • Electrolytes

Supplement Facts

Here's how Midlife Essentials typically works over time:

Week 1: You may feel more calm and less stressed immediately since the effects of L-theanine and GABA both work shortly after consumption and over time

Weeks 2-3: You may start to notice more energy support from the B-complex vitamins and electrolytes

Weeks 4-6: Mood stability and sleep quality improvement from Affron® saffron and magnesium glycinate 

Month 2: Gut health benefits and microbiome improvement from Bacillus coagulans Unique-IS2®; symptoms of perimenopause improve from Affron® saffron 

Month 3+: The full effects of essential nutrients like vitamin D3, choline and vitamin E, as well as other clinically studied ingredients will be felt and sustained with consistent use

Pour contents of one sachet into a glass. Add 8-12 oz of water, stir, and enjoy with a straw. Alternatively, swirl the glass before the last couple sips as natural settling will occur. Take at least once daily (with or without food).

Our Medical Advisory Board formulated Midlife Essentials to match published research at dosages proven to deliver results for women. This is uncommon in the supplement world–brands typically sprinkle many ingredients in too-small quantities.

Manufactured in US-based facilities at FDA registered sites, with cGMP certifications.We use third-party testing for independent verification of our quality. Ingredients included are Generally Recognized as Safe (GRAS). Our products are: 

  • Non-GMO
  • Gluten-free
  • Vegetarian*
  • No artificial flavors or colors
  • No sugar added

*contains shellac, a natural resin sourced from the Lac beetle

Designed to replace multiple supplements with one comprehensive solution for your hormonal stage.

Science & Research

Formulated with Purpose. Backed by Science.

Every ingredient in Midlife Essentials was selected by our Medical Advisory Board to address the real health concerns women experience during perimenopause while also ensuring overall nutritional needs are met.

60%

Increase in alpha ‘relaxation’ brainwaves versus placebo [1]

58%

Reduction in Mood Disturbance Scores in four weeks [2]

20%

Improvement in sleep quality ratings in 28 days [3]

60

Minutes until salivary cortisol level significantly drops [4]

Enhanced Absorption

Lifestage Specific

Science Backed Ingredients

Comprehensive Formula

Published In:
[1] Wellington Sleep Investigation Centre at the University of Otago in New Zealand with A. Campbell. [2] Complementary Therapies in Medicine (Volume 33, August 2017). [3] Sleep Medicine (Volume 86, October 2021). [4] BioFactors (Volume 26, 2006).

What’s inside

Our clinically backed ingredients

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MAXIMAL ABSORPTION. GENUINE DAILY ENJOYMENT.

What’s inside

Our clinically backed ingredients

Botanicals & Other Clinically-Backed Ingredients

Women in perimenopause often face more significant changes in their mental wellbeing. Sleep disruption can exacerbate these. We have used 28mg of Affron® saffron, along with 200mg Alphawave® L-Theanine and 100mg PharmaGABA® to help reduce feelings of overwhelm, tension and irritability associated with perimenopause, while working in concert with our essentials bioavailable vitamin and mineral complex to support your overall health. This targeted blend replaces multiple supplements with clinically-studied ingredients at research-backed dosages.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Saffron Extract
Clear plastic cup with red liquid on a red background L-theanine
Clear plastic cup with red liquid on a red background Gamma-Aminobutyric Acid (GABA)

Probiotics

Our clinically studied probiotic strain of Bacillus coagulans Unique-IS2® supports digestive health and stool regularity, and promotes a healthy microbiome that may help with nutrient availability for the gut cells and overall nutrient absorption. Gut health affects hormone metabolism and the gut-brain connection—the communication pathway between your digestive system and brain that influences mood, stress response, and energy levels throughout your cycle. Since your gut produces about 90% of your body's serotonin (a key mood neurotransmitter), supporting gut health directly impacts how you feel during your changing cycle as you move through perimenopause.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Bacillus Coagulans

Vitamins & Minerals

Essential nutrients in bioavailable forms to fill dietary gaps common during perimenopause. We include vitamin D3 for bone and immune support, calcium citrate and magnesium glycinate for bone and muscle health as well as better sleep, plus methylated B-vitamins and choline that your body, and brain, can readily use. These are provided in carefully balanced amounts to complement—rather than overwhelm—your system. This comprehensive vitamin and mineral complex replaces your daily multivitamin with targeted nutrition specifically formulated for perimenopausal women.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Magnesium
Clear plastic cup with red liquid on a red background Vitamin D3
Clear plastic cup with red liquid on a red background B-Vitamin Complex
Clear plastic cup with red liquid on a red background Vitamin K2

Electrolytes

Our electrolyte blend (200mg sodium, 100mg potassium) supports optimal hydration and nervous system function when made into a beverage. Unlike hydration products with up to 1000mg of sodium, our formulation delivers an amount more suitable without excess sodium that may cause bloating.

Ingredients Glossary
Clear plastic cup with red liquid on a red background Sodium
Clear plastic cup with red liquid on a red background Potassium

How we compare

Biologica Essentials deliver comprehensive nutrition and targeted relief, all designed for the woman who you are today.

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Greens

Multivitamins

Probiotics

Designed For Female Lifestages

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Alleviates Key Health Concerns

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Essential Vitamins and Minerals

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Clinically Studied Dosages

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Supports Gut Health

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Electrolytes

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WHAT’S BEHIND OUR LIFESTAGE FORMULATIONS

THE SCIENCE OF PERIMENOPAUSE

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Perimenopause can last for up to 10 years prior to menopause, with declining progesterone and unpredictable estrogen fluctuations. This hormonal change affects neurotransmitters like serotonin and GABA, leading to sleep disruption, mood changes, and cognitive challenges like brain fog. Midlife Essentials removes the guesswork, and delivers a co-pilot for your hormones during this major life transition.

Learn more — hormones 101

TASTES LIKE A DAILY RITUAL SHOULD

We tested dozens of flavors because your daily supplement shouldn't taste like medicine. As a result of this research, and without any sugar, each Biologica Essential comes in a range of indulgent, flavor-forward options from fruit from real farms—think bright, juicy, and never too sweet. It's the kind of daily ritual you'll actually want to maintain.

Product Reviews

4.8
Rated 4.8 out of 5 stars
Based on 74 reviews
95%would recommend this product
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    Melissa
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    I recommend this product
    Rated 5 out of 5 stars
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    I feel better

    In the past Id taken several of these ingredients separately. This is convenient and I do think I feel better when I take it

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    Corynn M.
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    I recommend this product
    Rated 5 out of 5 stars
    5 days ago
    Game changer for my premenstrual migraines

    I’m in month 4 of taking Midlife Essentials daily and I haven’t had my typical premenstrual migraines the last three cycles! I’m hooked on Biologica.

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Frequently Asked Questions

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Citations

#1 60% Increase in alpha ‘relaxation’ brainwaves versus placebo

"A randomized, double-blind, placebo-controlled study to assess the effects of AlphaWave® L-Theanine on relaxation as measured by EEG."

  • Wellington Sleep Investigation Centre at the University of Otago in New Zealand with A. Campbell
  • This specific 2017 trial was released as a clinical white paper.
  • The 60% Statistic: this figure refers to the 60% increase in alpha-wave power in the frontal region of the brain compared to the placebo group. This effect was observed significantly at the 200 mg dose within a very short timeframe.

58% Reduction in Mood Disturbance Scores in four weeks

"affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial."

  • Authors: Kell, G., Rao, A., Beccaria, G., Clayton, P., et al.
  • Published In: Complementary Therapies in Medicine (Volume 33, August 2017).
  • The 58% Statistic: the 58% figure is a commonly cited calculation from this specific trial's data. It represents the percentage decrease in the Total Mood Disturbance (TMD) score for participants taking the 28 mg/day dose compared to their baseline after 4 weeks.

20% Improvement in sleep quality ratings in 28 days

"An investigation into an evening intake of a saffron extract (affron®) on sleep quality, cortisol, and melatonin concentrations in adults with poor sleep: a randomised, double-blind, placebo-controlled, multi-dose study."

  • Authors: Lopresti, A. L., Smith, S. J., & Drummond, P. D.
  • Published In: Sleep Medicine (Volume 86, October 2021).
  • The 20% Statistic: refers to a 20% increase in the Restorative Sleep Questionnaire (RSQ) score after 28 days of supplementation. The RSQ measures how "restored" or energized a person feels upon waking, rather than just the number of hours they slept.

60 Minutes until salivary cortisol level significantly drops

"Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans."

  • Authors: Abdou, A. M., Higashiguchi, S., Horie, K., Kim, M., Hatta, H., & Yokogoshi, H.
  • Published In: BioFactors (Volume 26, 2006).
  • The 60-Minute Statistic: salivary cortisol levels significantly dropped 60 minutes after administration, coinciding with an increase in alpha brainwaves and a decrease in beta waves (markers of relaxation).