maybe an image about Vitamin K2

Role Of Vitamin K2 in the body

  • SUPPORTS OPTIMAL CALCIUM TRAFFICKING — activates the essential proteins that direct calcium from your bloodstream to bone tissue helping to maintain its proper distribution

  • SUPPORTS BONE MINERALIZATION — helps maintain bone mineralization and structural integrity through sustained activation of osteocalcin and matrix proteins binding calcium to bone

  • SUPPORTS HEART HEALTH — promotes healthy calcium metabolism by ensuring calcium is directed to your bones for storage, and away from your arteries

Why We Use It

Vitamin K2 (as MK-7 [Menaquinone-7]) - menatto®

Vitamin K2 is the essential coordinator that manages calcium metabolism in your body. K2 as Menaquinone-7 (MK-7) is the most effective and longest-lasting form of Vitamin K2 due to its longer half life, which is why we've chosen the branded ingredient menatto®, backed by robust clinical data.

Our Primary Essentials, Midlife Essentials, and Postmenopause Essentials all contain Vitamin K2, because of its crucial role in bone and heart health, and its status as an often under-consumed nutrient.

Calcium is the building block of bone, but it needs an architect to direct it. That's where Vitamin K2 comes in. It functions as a cofactor for an enzyme called gamma-glutamyl carboxylase, which activates a specific protein called osteocalcin. When activated by MK-7, osteocalcin can bind to calcium, helping to incorporate it into your bone matrix. This process is crucial for bone mineralization and maintaining structural integrity. Without enough active osteocalcin, calcium may not be properly utilized for bone formation, reducing the effectiveness of your calcium and Vitamin D supplements.

The same activation process that benefits your bones, also supports your arteries. Vitamin K2 activates another protein called Matrix Gla Protein (MGP), which is found in blood vessels and soft tissues. Activated MGP functions as an inhibitor of vascular calcification, meaning it helps to keep calcium from building up in artery walls. By ensuring that calcium is directed to where it belongs (your bones) and not where it shouldn't be (your arteries), Vitamin K2 plays a key role in supporting the health of your cardiovascular system.

While other forms of Vitamin K exist, MK-7 stands out due to its superior bioavailability and longer half-life. Unlike other forms that are quickly cleared from the body, MK-7 remains in the bloodstream for more than 48-hours. This provides sustained activation of both osteocalcin and MGP, offering a consistent level of support for your bones and arteries.

The increasing dose in our formulas as you age reflects a simple truth: calcium utilization becomes more crucial as women age and estrogen's bone-protective effects decline. Our targeted dosages provide specific support across different hormonal life stages.

In Your Formula

You’ll find Vitamin K2 in:

References

  • Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

    Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12;11:93.

  • Vitamin K2 in bone metabolism and osteoporosis

    Plaza SM, Lamson DW. Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev. 2005 Mar;10(1):24-35.

  • Vitamin K in the treatment and prevention of osteoporosis and arterial calcification

    Adams J, Pepping J. Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. Am J Health Syst Pharm. 2005 Aug 1;62(15):1574-81.

  • Proper Calcium Use: Vitamin K2 as a Promoter of Bone and CardiovascularHealth

    Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and CardiovascularHealth. Integr Med (Encinitas). 2015 Feb; 14(1): 34–39.