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Role Of Chasteberry Extract in the body
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SUPPORTS HORMONAL HEALTH — maintains healthy estrogen and progesterone ratios throughout your cycle, working with your body's natural hormonal rhythms
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MAINTAINS EMOTIONAL STABILITY — helps reduce irritability and emotional fluctuations, common symptoms associated with the menstrual cycle
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REDUCES PREMENSTRUAL DISCOMFORT including mood changes, breast tenderness, and menstrual cramps
Why We Use It
Chasteberry Extract (Vitex agnus-castus) (fruit)
Chasteberry (Vitex or Monk's Pepper) has been used by women for over 2,500 years. Our Primary Essentials contains 40mg of chasteberry extract because it's one of the best researched botanicals to help with the physical and emotional changes associated with the menstrual cycle. This isn't folklore: it's centuries-old use validated by modern science.
Chasteberry works through the hypothalamic-pituitary-gonadal (HPG) axis, your reproductive system's command center. Chasteberry has been shown to modulate dopamine D2 receptor (D2R) activity in the anterior pituitary, which regulates prolactin.
Prolactin is one of the primary hormones behind some of the symptoms associated with your monthly cycle. By supporting healthy prolactin levels, chasteberry helps support a healthy balance between estrogen and progesterone ratios throughout your cycle.
In addition, Chasteberry may also interact with opioid receptors, and aid in a healthy response to balancing menstrual or muscle cramps. This suggests an additional mechanism for which Chasteberry may be helpful for symptoms associated with the menstrual cycle.
We use the clinically validated 40mg dose proven effective in published research because you deserve to feel your best throughout your cycle. Changes to your cycle generally take a number of months, but the research speaks for itself: a 3-cycle study showed over 50% of women experienced a 50% or greater reduction in common premenstrual discomforts and changes including: irritability, breast tenderness, headaches and mood swings.
Chasteberry works through the hypothalamic-pituitary-gonadal (HPG) axis, your reproductive system's command center. Chasteberry has been shown to modulate dopamine D2 receptor (D2R) activity in the anterior pituitary, which regulates prolactin.
Prolactin is one of the primary hormones behind some of the symptoms associated with your monthly cycle. By supporting healthy prolactin levels, chasteberry helps support a healthy balance between estrogen and progesterone ratios throughout your cycle.
In addition, Chasteberry may also interact with opioid receptors, and aid in a healthy response to balancing menstrual or muscle cramps. This suggests an additional mechanism for which Chasteberry may be helpful for symptoms associated with the menstrual cycle.
We use the clinically validated 40mg dose proven effective in published research because you deserve to feel your best throughout your cycle. Changes to your cycle generally take a number of months, but the research speaks for itself: a 3-cycle study showed over 50% of women experienced a 50% or greater reduction in common premenstrual discomforts and changes including: irritability, breast tenderness, headaches and mood swings.
References
Treatment for the premenstrual syndrome with agnus castus fruit extract
Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001;322(7279):134-7.
Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome
Zamani M, Neghab N, Torabian S. Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome. Acta Med Iran. 2012;50(2):101-6.
Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS)
Berger D, Schaffner W, Schrader E, Meier B, Brattström A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet. 2000;264(3):150-3.
Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp
Kamal N, Mio Asni NS, Rozlan INA, Mohd Azmi MAH, Mazlan NW, Mediani A, Baharum SN, Latip J, Assaw S, Edrada-Ebel RA. Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp. Plants (Basel). 2022 Jul 26;11(15):1944.
"Chasteberry."
Roemheld-Hamm, Beatrix. "Chasteberry." American Family Physician, vol. 72, no. 5, 1 Sept. 2005, pp. 821-824.
Vitex agnus castus Extract Ze 440: Diterpene and Triterpene’s Interactions with Dopamine D2 Receptor
Reinhardt, J. K., Schertler, L., Bussmann, H., Sellner, M., Smiesko, M., Boonen, G., Potterat, O., Hamburger, M., & Butterweck, V. (2024). Vitex agnus castus Extract Ze 440: Diterpene and Triterpene’s Interactions with Dopamine D2 Receptor. International Journal of Molecular Sciences, 25(21), 11456.
