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Role Of Saffron Extract in the body
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SUPPORTS EMOTIONAL WELL-BEING — helps you maintain a positive outlook and emotional stability throughout your cycle and during hormonal transitions, like perimenopause
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PROMOTES RESTFUL SLEEP when used during the day, as it works with your body's natural sleep-wake cycle and neurotransmitter system, for a deeper sleep
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STRESS RESILIENCE — supports a calm mindset during occasional stress and daily challenges
Why We Use It
Saffron Extract (Crocus sativus L.) (stigma) - Affron®
Hormonal shifts can impact how you feel and your overall emotional well-being. Our Primary Essentials and Midlife Essentials both contain Affron®, a clinically studied saffron extract that helps support a normal healthy mood.
Affron®, a proprietary saffron extract (Crocus sativus L.), is created using a highly precise extraction process to help maintain the activity of its bioactive compounds, from the saffron flower. The extract is standardized to provide the beneficial compounds, crocins and safranal, which are believed to support your brain’s neurotransmitter systems. It is thought to influence the healthy function of pathways that relate to mood, sleep, and your stress response.
Affron® has been the subject of multiple randomized, double-blind, placebo-controlled clinical trials to assess its effect on mood, emotional well-being, and sleep quality. These studies, conducted on healthy adults with self-reported challenges, but no clinical diagnoses of mood or sleep disorders, provide evidence for the extract's beneficial properties.
Research on mood and emotional health has demonstrated that a daily intake of 28mg of Affron® can positively influence emotional well-being. Participants taking this dose reported improvements in overall mood, with a notable decrease in feelings of tension, stress, and anxiousness. The data also indicated a positive shift in feelings of vigor and a balanced emotional state. These findings support Affron®'s ability to promote a balanced mood and healthy emotional state.
For women in perimenopause, studies have shown that Affron® helps maintain a calm and positive mindset. In trials focused on sleep, the use of Affron® during the daytime was associated with improvements in sleep quality. Studies found that the extract helped individuals with self-reported sleep challenges reduce the time it takes to fall asleep and decrease occasional daytime grogginess. These results suggest that Affron® supports healthy sleep patterns and helps promote restorative rest.
The consistency of these findings across multiple studies using validated assessment tools—such as the Profile of Mood States (POMS), Insomnia Severity Index (ISI), and Depression, Anxiety, and Stress Scale (DASS-21)—provides a strong basis for the reliability of Affron®. The research collectively demonstrates that Affron® can be a valuable supplement for individuals seeking to support mood, perimenopausal shifts, and achieve more restful sleep.
Affron®, a proprietary saffron extract (Crocus sativus L.), is created using a highly precise extraction process to help maintain the activity of its bioactive compounds, from the saffron flower. The extract is standardized to provide the beneficial compounds, crocins and safranal, which are believed to support your brain’s neurotransmitter systems. It is thought to influence the healthy function of pathways that relate to mood, sleep, and your stress response.
Affron® has been the subject of multiple randomized, double-blind, placebo-controlled clinical trials to assess its effect on mood, emotional well-being, and sleep quality. These studies, conducted on healthy adults with self-reported challenges, but no clinical diagnoses of mood or sleep disorders, provide evidence for the extract's beneficial properties.
Research on mood and emotional health has demonstrated that a daily intake of 28mg of Affron® can positively influence emotional well-being. Participants taking this dose reported improvements in overall mood, with a notable decrease in feelings of tension, stress, and anxiousness. The data also indicated a positive shift in feelings of vigor and a balanced emotional state. These findings support Affron®'s ability to promote a balanced mood and healthy emotional state.
For women in perimenopause, studies have shown that Affron® helps maintain a calm and positive mindset. In trials focused on sleep, the use of Affron® during the daytime was associated with improvements in sleep quality. Studies found that the extract helped individuals with self-reported sleep challenges reduce the time it takes to fall asleep and decrease occasional daytime grogginess. These results suggest that Affron® supports healthy sleep patterns and helps promote restorative rest.
The consistency of these findings across multiple studies using validated assessment tools—such as the Profile of Mood States (POMS), Insomnia Severity Index (ISI), and Depression, Anxiety, and Stress Scale (DASS-21)—provides a strong basis for the reliability of Affron®. The research collectively demonstrates that Affron® can be a valuable supplement for individuals seeking to support mood, perimenopausal shifts, and achieve more restful sleep.
In Your Formula
You’ll find Saffron Extract in:
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Primary Essentials$70 $59 -
Midlife Essentials$70 $59
References
Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases
Yang W, Qiu X, Wu Q, Chang F, Zhou T, Zhou M, Pei J. Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases (Review). Exp Ther Med. 2023 Apr 3;25(5):235.
Saffron: An Old Medicinal Plant and a Potential Novel Functional Food
José Bagur M, Alonso Salinas GL, Jiménez-Monreal AM, Chaouqi S, Llorens S, Martínez-Tomé M, Alonso GL. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food. Molecules. 2017 Dec 23;23(1):30.
Potential Role of Phytochemical Extract from Saffron in Development of Functional Foods and Protection of Brain-Related Disorders
Maqbool Z, Arshad MS, Ali A, Aziz A, Khalid W, Afzal MF, Bangar SP, Addi M, Hano C, Lorenzo JM. Potential Role of Phytochemical Extract from Saffron in Development of Functional Foods and Protection of Brain-Related Disorders. Oxid Med Cell Longev. 2022 Sep 22;2022:6480590.
affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial
Kell G, Rao A, Beccaria G, Clayton P, Inarejos-Garcia AM, Prodanov M. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine. 2017;33:58-64.
The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause
Lopresti AL, Smith SJ. The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. J Menopausal Med. 2021;27(2):66-78.
Sleep enhancement by saffron extract affron® in randomized control trial
Nishide A, Fujita T, Nagaregawa Y, et al. Sleep enhancement by saffron extract affron® in randomized control trial. Japanese Pharmacology and Therapeutics. 2018;46(8):1407-1415.
Effects of saffron on sleep quality in healthy adults with self-reported poor sleep
Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020;16(6):937-947.
